Washington Center For Psychiatry

New Brain Discoveries
Salerian Brain Laws #1 and #2 (SBL1 and SBL2):
Frontal Cortex Function and Dopamine Govern Mood and Executive Function

By Alen J. Salerian, MD
I am excited to share two of my discoveries of brain function and dysfunction, two novel theories I advance about the essence of all neuropsychiatric disorders.  Region specific dysfunction and abnormal neurotransmission [...]

CNS Spectrums 2007; 13(3):227-229
By Alen J Salerian, MD, Nansen G. Saleri, PhD
Focus Points
• Reduction of core body temperature has been proposed to contribute to increased lifespan and the anti-aging effects conferred by caloric restriction in mice and higher primates.
• Having cooler biologically compatible core body temperatures may also combat neurodegenerative disorders.
• Engineered transgenic mice were [...]

Link
Medical Hypotheses
December 2005
By Alen J. Salerian, MD and Nansen G. Saleri, PhD

Summary

Scientific evidence suggests the critical role of temperature in regulating three mechanisms contributing to cellular damage: Oxidative stress, oxygen demand overload and inflammation. In this article, we propose that the Arrhenius rate law has a profound impact on aging and a variety of neurodegenerative [...]